Model for End-Stage Liver Disease

A Model to Predict Survival in Patients With End-Stage Liver Disease.

Dialysis in the past week
+1
Creatinine
Bilirubin
INR
Sodium
     
  • If patient had dialysis in the past week the value for Creatinine is 4.
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  • Na+ must be corrected for hyperglycemia with Na = Measured Sodium + 0.016 * (Glucose - 100)
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  • MELD(i) = [9.57 ln creatinine mg/dL + 3.78 * ln bilirubin mg/dL 11.20 ln INR + 6.43*10]
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  • MELD = MELD(i) + 1.32 × (137 – Na) – [0.033 × MELD(i) × (137 – Na)]
Derivation Reference:

Kamath, P.S., Wiesner, R.H., Malinchoc, M., Kremers, W., Therneau, T.M., Kosberg, C.L., D’Amico, G., Dickson, E.R., Kim, W.R. A Model to Predict Survival in Patients with End-Stage Liver Disease. Hepatology (Baltimore, Md.) 33, no. 2 (February 2001): 464–70. doi:10.1053/jhep.2001.22172.

Validation Reference:

Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P., Kremers, W., et al. Model for End-Stage Liver Disease (MELD) and Allocation of Donor Livers. Gastroenterology 124, no. 1 (January 2003): 91–96. doi:10.1053/gast.2003.50016.